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2025-03-27

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개요

• 극소저체중아 레지스트리(Korean Neonatal Network, KNN)는 고위험 신생아의 치료 및 예후를 파악하고 이를 통해 미숙아 중재기술 개발 및 생존률 향상을 달성하기 위한 국가규모 임상연구사업입니다.

추진 경과

• 2013년부터 70개 이상의 병원이 참여하는 전국적인 다기관 임상네트워크(그림 참조)를 구축하여 매년 출생체중 1,500그램 미만 또는 임신나이 32주 미만 미숙아의 80% 이상을 등록하고 있습니다. 현재까지(2024.12 기준) 약 2만 5천명을 등록하였으며, 퇴원 후 만 1.5세 및 만 3세에 추적조사를 수행하고 있습니다.
• 2022년부터 미숙아 치료수준을 전국적으로 상향평준화 시키기 위한 다양한 신생아집중치료 질 향상(Quality Improvement, QI) 프로그램(모유수유, 감염관리, 인공호흡기케어, 입실체온향상)을 운영하고 있으며, 향후 프로그램의 중·장기적 합병증 개선 및 생존율 향상 효과를 분석하여, 실효성 있는 프로그램을 확대 운영함으로써 미숙아의 생존율 항상 및 건강증진에 기여하고자 합니다.
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  KNN 참여기간

  • 서울(27)
  • 인천/경기(20)
  • 호남(4)
  • 제주(1)
  • 강원(3)
  • 대전/충청(7)
  • 대구/경북(5)
  • 부산/경남(11)

주요 성과

• 논문목록
  • 2024년
  • 2023년
  • 2022년
  • 2021년
  • 2020년
  • 2019년

  해당 관련 논문목록과 초록보기 링크 제공

  Factors affecting length of stay according to bronchopulmonary dysplasia severity: a nationwide cohort study in Korea. World Journal of Pediatrics 2024;20(5):470-480	초록보기
  The effect of minimizing central line days for very low birth weight infants through quality improvement. Scientific Reports 2024;14(1):3854	초록보기
  Long-term impact of late pulmonary hypertension requiring medication in extremely preterm infants with severe bronchopulmonary dysplasia. Scientific Reports 2024;14(1):8705	초록보기
  Analysis of perinatal risk factors for massive pulmonary hemorrhage in very low birth weight infant: A nationwide large cohort database. Early Human Development 2024;191:105977	초록보기
  Current Status and Associated Factors of Post-Hemorrhagic Hydrocephalus in Infants of 22 to 28 Weeks Gestation With Severe Intraventricular Hemorrhage in Korea: A Nationwide Cohort Study. Journal of Korean Medical Science 2024;39(15):e139	초록보기
  Neonatal outcomes of preterm infants with pulmonary hypertension: clustering based on prenatal risk factors. Pediatric Research 2024;96(5):1251-1257	초록보기
  Predicting severe intraventricular hemorrhage or early death using machine learning algorithms in VLBWI of the Korean Neonatal Network Database. Scientific Reports 2024;14(1):11113	초록보기
  Postnatal Growth Assessment and Prediction of Neurodevelopment and Long-Term Growth in Very Low Birth Weight Infants: A Nationwide Cohort Study in Korea. Journal of Clinical Medicine 2024;13(10):2930	초록보기
  Quality Improvement Project to Reduce Admission Hypothermia of Preterm Infants Born at Less than 32 Weeks or 1,500 g. Neonatal Medicine 2024;31(2):38-46	초록보기
  Machine learning-based analysis for prediction of surgical necrotizing enterocolitis in very low birth weight infants using perinatal factors: a nationwide cohort study. European Journal of Pediatrics 2024;183(6):2743-2751	초록보기
  Neonatologist staffing is related to the inter-hospital variation of risk-adjusted mortality of very low birth weight infants in Korea. Scientific Reports 2024;14(1):20959	초록보기
  Impact of COVID-19 pandemic on neurodevelopmental outcome in very low birth weight infants: a nationwide cohort study. Frontiers in Pediatrics 2024;12:1368677	초록보기
  Outcomes at 18-24 Months of Infants with Birth Weight under 500 g Born in Korea during 2013-2017: A Nationwide Cohort Study. Neonatology 2024;121(1):74-80	초록보기
  Risk factors for refractory respiratory distress syndrome among very-low-birth-weight infants. BMC pediatrics 2024;24(1):677	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  Role of birthweight discordance in preterm twins’ outcomes in the Korean neonatal network Pediatrics and Neonatology 2023;64(5)	초록보기
  Effects of antenatal corticosteroids on neonatal outcomes in twin and singleton pregnancies: a Korean national cohort study BMJ Paediatrics Open 2023;7(1)	초록보기
  Impact of time to full enteral feeding on long‑term neurodevelopment without mediating by postnatal growth failure in very‑low‑birth‑weight‑infants Scientific Reports 2023;13(1)	초록보기
  On the 10th Anniversary of the Korean Neonatal Network Neonatal medicine 2023;30(1)	초록보기
  Required biological time for lung maturation and duration of invasive ventilation: a Korean cohort study of very low birth weight infants Frontiers in Pediatrics 2023;11:1184832	초록보기
  Risk factors and neonatal outcomes of pulmonary air leak syndrome in extremely preterm infants: A nationwide descriptive cohort study Medicine 2023;102(34)	초록보기
  Outcomes of singleton preterm very low birth weight infants born to mothers with pregnancy-induced hypertension Scientific Reports 2023;13(6100)	초록보기
  Variations in medical practice of retinopathy of prematurity among 8 Asian countries from an international survey Scientific Reports 2023;13(1)	초록보기
  Comparison of mortality and short-term outcomes between classic, intubation-surfactant-extubation, and less invasive surfactant administration methods of surfactant replacement therapy Frontiers in Pediatrics 2023;11:1197607	초록보기
  Comparison of neonatal outcomes between multiples and singletons among very low birth weight infants: the Korean Neonatal Network cohort study The Journal of Maternal-Fetal & Neonatal Medicine 2023;36(2)	초록보기
  Neonatal Intensive Care Quality Level-Dependent Variations in the Survival Rate of Infants with a Birth Weight of 500 g or Less in Korea: A Nationwide Cohort Study Neonatology 2023;120(1)	초록보기
  Learning-Based Longitudinal Prediction Models for Mortality Risk in Very-Low-Birth-Weight Infants: A Nationwide Cohort Study Neonatology 2023;120(5)	초록보기
  Factors associated with the response to postnatal dexamethasone use in very low birthweight infants: a nationwide cohort study BMJ Paediatrics Open 2023;7(1)	초록보기
  Artificial Intelligence-Driven Respiratory Distress Syndrome Prediction for Very Low Birth Weight Infants: Korean Multicenter Prospective Cohort Study JOURNAL OF MEDICAL INTERNET RESEARCH 2023;25:e47612	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  Neurodevelopmental outcomes of preterm infants with very low birth weight conceived with the assistance of in vitro fertilization Fertility and Sterility 2022;117(6)	초록보기
  Retinopathy of Prematurity Requiring Treatment Is Closely Related to Head Growth during Neonatal Intensive Care Unit Hospitalization in Very Low Birth Weight Infants Neonatology 2022;119(2)	초록보기
  Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study Scientific Reports 2022;12(1)	초록보기
  Dose completion of antenatal corticosterioids and neonatal outcomes in non-small-for-gestational age or small-for-gestational age very-low-birth weight infants: a Korean population-based cohort study Pediatrics and Neonatology 2022;63(2)	초록보기
  Growth Pattern With Morbidities From Birth to 5 Years of Age in Very Low Birth Weight Infants: Comparison of the Korean National Network and National Health Insurance Service Journal of Korean Medical Science 2022;37(20)	초록보기
  Effects of Ponderal Index on Neonatal Mortality and Morbidities in Extremely Premature Infants Journal of Korean Medical Science 2022;37(40)	초록보기
  Serial Short-Term Outcomes of Very-Low-Birth-Weight Infants in the Korean Neonatal Network From 2013 to 2020 Journal of Korean Medical Science 2022;37(29)	초록보기
  Thyroid Dysfunction and the Effect of Iodine-Deficient Parenteral Nutrition in Very Low Birth Weight Infants: A Nationwide Analysis of a Korean Neonatal Network Database Nutrients 2022;14(15)	초록보기
  Application of Machine Learning Approaches to Predict Postnatal Growth Failure in Very Low Birth Weight Infants Yonsei Medical Journal 2022;63(7)	초록보기
  Serial Long-term growth and neurodevelopment of very-low-birth-weight infants: 2022 update on the Korean Neonatal Network Journal of Korean Medical Science 2022;37(34)	초록보기
  Impact of Outborn/Inborn Birth Status of Infants Born at 29 Weeks of Gestation on neurodevelopmental impairment: A Nationwide Cohort Study in Korea International Journal of Environmental Research and Public Health 2022;19(18)	초록보기
  Cystic Periventricular Leukomalacia Worsens Developmental Outcomes of Very-Low-Birth Weight Infants with Intraventricular Hemorrhage—A Nationwide Cohort Study Journal of Clinical Medicine 2022;11(19)	초록보기
  Comparison of definitions of bronchopulmonary dysplasia to reflect the long‑term outcomes of extremely preterm infants Scientific Reports 2022;12(1)	초록보기
  Association Between Retinopathy of Prematurity in Very-Low-Birth-Weight Infants and Neurodevelopmental Impairment American Journal of Ophthalmology 2022;244	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  Prediction of In-hospital Mortality after 24 Hours in Very Low Birth Infants Pediatrics 2021;147(1)	초록보기
  Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants Scientific Reports 2021;11(1)	초록보기
  Mortality and Morbidities According to Time of Birth in Extremely Low Birth Weight Infants Journal of Korean Medical Science 2021;36(13)	초록보기
  The Prediction of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants through Clinical Indicators within 1 Hour of Delivery Journal of Korean Medical Science 2021;36(11)	초록보기
  Neonatal Outcomes according to the Latent Period from Membrane Rupture to Delivery among Extremely Preterm Infants Exposed to Preterm Premature Rupture of Membrane: a Nationwide Cohort Study Journal of Korean Medical Science 2021;36(14)	초록보기
  Survival and Morbidities in Infants with Birth Weight Less than 500g: a Nationwide Cohort Study Journal of Korean Medical Science 2021;36(31)	초록보기
  Risk factors and prognosis in very low birth weight infants treated for hypotension during the first postnatal week from the Korean Neonatal Network PLOS ONE 2021;16(10)	초록보기
  Cesarean section was not associated with mortality or morbidities advantage in very low birth weight infants: a nationwide cohort study Scientific Reports 2021;11(1)	초록보기
  Differences in Comorbidities and Clinical Burden of Severe Bronchopulmonary Dysplasia Based on Disease Severity Frontiers in Pediatrics 2021;9:664033	초록보기
  Artificial intelligence model comparison for risk factor analysis of patent ductus arteriosus in nationwide very low birth weight infants cohort Scientific Reports 2021;11(1)	초록보기
  Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes Scientific Reports 2021;11(1)	초록보기
  Growth failure of very low birth weight infants during the first 3 years: A Korean Neonatal Network PLOS ONE 2021;16(10)	초록보기
  Definitions of bronchopulmonary dysplasia and long‑term outcomes of extremely preterm infants in Korean Neonatal Network Scientific Reports 2021;11:24349	초록보기
  Retinopathy of Prematurity and Hearing Impairment in Infants Born with Very-Low-Birth-Weight: Analysis of a Korean Neonatal Network Database Journal of Clinical Medicine 2021;10(20)	초록보기
  Neurodevelopmental Outcomes at 18–24 Months of Corrected Age in Very Low Birth Weight Infants with Late-onset Sepsis Journal of Korean Medical Science 2021;36(35)	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  The Association of Pregnancy-induced Hypertension with Bronchopulmonary Dysplasia- A Retrospective Study Based on the Korean Neonatal Network database Scientific Reports 2020;10:5600	초록보기
  Extrauterine growth restriction in extremely preterm infants based on the Intergrowth-21st Project Preterm Postnatal Follow-up Study growth charts and the Fenton growth charts European Journal of Pediatrics 2020;180(3)	초록보기
  Survival Rate Dependent Variations in Retinopathy of Prematrity Treatment Rates in Very Low Birth Weight Infants Scientific Reports 2020;10(1)	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  A clinical scoring system to predict the need for extensive resuscitation at birth in very low birth weight infants BMC Pediatrics 2019;19(197)	초록보기
  Clinical impact of admission hypothermia in very low birth weight infants: results from Korean Neonatal Network Korean J Pediatr 2019;62(10)	초록보기
  Comparison of neonatal outcomes of very low birth weight infants by mode of conception: in vitro fertilization versus natural pregnancy EPIDEMIOLOGY 2019;111(5)	초록보기
  Histological chorioamnionitis, antenatal steroids, and neonatal outcomes in very low birth weight infants: A nationwide study PLOS ONE 2019;14(10)	초록보기
  Implementation of the Korean Neonatal Network American Academy of Pediatrics 2019;20(4)	초록보기
  Late-Onset Sepsis as a Risk Factor for Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants: A Nationwide Cohort Study Scientific Reports 2019;9:15448	초록보기
  Length at birth z-score is inversely associated with an increased risk of bronchopulmonary dysplasia or death in preterm infants born before 32 gestational weeks: A nationwide cohort study PLOS ONE 2019;14(5)	초록보기
  Mortality rate-dependent variations in the survival without major morbidities rate of extremely preterm infants Scientific Reports 2019;9:7371	초록보기
  Mortality Rate-Dependent Variations in the Timing and Causes of Death in Extremely Preterm Infants Born at 23–24 Weeks’ Gestation Neonatal Intensive Care 2019;20(7)	초록보기
  Neonatal Outcomes of Very Low Birth Weight Infants in Korean Neonatal Network from 2013 to 2016 J Korean Med Sci 2019;34(5)	초록보기
  The Incidence and Survival Rate of Very Low Birth Weight Infants in Korea (2013-2016): A Comparison of the Statistics Korea and the Korean Neonatal Network and Improvements perinatology 2019;30(1)	초록보기
  Validity of the Korean Developmental Screening Test for very-low-birth-weight infants Korean J Pediatr 2019;62(5)	초록보기
  The Impact of Surgical Intervention on Neurodevelopmental Outcomes in Very Low Birth Weight Infants: a Nationwide Cohort Study in Korea J Korean Med Sci 2019;34(43)	초록보기