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HPV Cohort Study

The Korea HPV cohort study was established in 2009. It is an observational study of HPV-infected women aged 20-60 years. Women that are HPV-positive for both atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) of the cervix were enrolled through the HPV cohort study implemented in 5 hospitals. The goals of this cohort study are as follows: (1) to study the epidemiology of persistent HPV infection, (2) to investigate whether persistent HPV infection increases the risk of low-grade and high-grade cervical lesions, and (3) to elucidate the genetic and immunological determinants of persistent HPV infection. To achieve these goals, the 655 individuals have been registered, and followed-up every 6 months. The collected samples (serum, plasma, buffy coat, Cervix cell DNA) and clinical data have been deposited at the bio-bank and database system for future HPV projects.