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Korean Children & Adolescents Obesity Cohort Study
Concurrent with the remarkable increase in adult obesity, Korean children have also become heavier. The proportion of children (age 6-11) who exceed the 95th percentile cut-off for 2007 KCDC BMI for age growth chart or the BMI 25kg/m2 increased from 5.8% in 1998 to 10.0% in 2013 (1998, 2013 KNHNES). Childhood obesity typically persists into adulthood and increases the risk for insulin resistance and metabolic syndrome-related conditions, such as increased blood pressure abnormal glucose and lipid metabolism. Therefore, early detection of individuals at risk of being overweight may have long-term health benefits.
The objectives of the children & adolescents obesity cohort are to prospectively investigate the children’s health and lifestyles with collect biological samples. By analyzing the data collected from this cohort, such as changes in many indices purported to be related to obesity and metabolic disorders in children, we could be able to identify biomarkers for childhood obesity, and to assess the efficacy of preventive or therapeutic measures.
The subjects in this cohort were followed from their enrollment in elementary school at age 7 until the 1th grade of high school, when students were aged 16. The children were recruited from Gwacheon City. Anthropometric and genetic data, such as common disease gene variants, indices of metabolic disease, and information on food and nutrient intake have been collected from the children. Another 1,900 subjects aged 7 and 10 in Junggu, Seoul, and the southwestern area of Kyunggi Province, were added in 2008. We were followed the subjects recruited from Gwacheon City, Junggu, Seoul, and the southwestern area of Kyunggi Provinces they enter middle and high school in 2011 and 2014, and were also enrolled as new participants from the middle schools of the follow-up subjects. The morbid obese adolescent cohort was newly established between 2012 and 2013 as part of the children & adolescents obesity cohort study from Seoul and Kyunggi province, Korea. The objective of this cohort was to identify predictors of morbid obesity, and associated metabolic disease in Korean children. The subjects who exceed the 99th percentile cut-off for 2007 KCDC BMI for age growth chart or the BMI 30kg/m2 were recruited. Recruitment of the cohort of qualified participants took place at Seoul-Paik Hospital, Inje University and Hallym University Medical Center. We will conduct intervention study of morbid obesity in this cohort.
We expect this project to generate new findings on obesity candidate genes and variants, and hope to develop an obesity prevention program. The previously performed clinical and physiological examinations and lifestyle data collection will be repeated. We will continue to collect information on children’s health, and to identify biomarkers associated with the development or control of childhood obesity in order to develop protective and therapeutic approaches to this issue.