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The U-shaped association between achieved blood pressure and risk of cardiovascular events and ...
  • Date2021-02-23 17:13
  • Update2021-02-23 17:13
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

Journal of hypertension, 2020.38, 1559-1566, DOI: https://doi.org/10.1097/HJH.0000000000002434


The U-shaped association between achieved blood pressure and risk of cardiovascular events and mortality in elderly and younger patients

Nam-Kyoo Lim, Hyun-Young Park; Won-Ho Kim; Giuseppe Mancia; Myeong-Chan Cho


Abstract

    Objective: The main objective is to assess the appropriate level of achieved SBP and DBP to prevent cardiovascular events.
    Methods: We used the National Sample Cohort from the National Health Insurance Service in Korea and analyzed data of 44 462 hypertensive patients aged 20–84 years. Achieved SBP and DBP were categorized according to average achieved SBP (<120, 120–129, 130–139, 140–149, and 150 mmHg) and DBP (<70, 70–79, 80–89, 90–99, and 100 mmHg). We examined the association between achieved BP and composite outcome including cardiovascular death, admission of stroke, myocardial infarction, or heart failure, and allcaused death in elderly aged more than 65 years and in younger patients.
    Results: After a median follow-up of 6.8 years, achieved SBP less than 120mmHg and at least 150mmHg in elderly and younger patients, respectively, were significantly associated with a higher risk of composite outcome than achieved SBP of 120–129 mmHg. Cox’s proportional hazard analysis showed that the association between achieved SBP and risk of composite outcome and all-cause death had U-shaped relationships and identified a nadir of SBP of 135.6 and 128.9mmHg, respectively, for composite outcome and 135.1 and 131.4 mmHg, respectively, for all-cause death in elderly and younger patients.
    Conclusion: Compared with SBP of 120–129 mmHg, not only low achieved SBP of less than 120mmHg but also high BP are associated with risk of adverse cardiovascular event and all-cause death in both elderly and younger patients with a distinct U-shaped relationship.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
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