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Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype depending ...
  • Date2021-02-23 16:46
  • Update2021-02-23 16:46
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

Pediatr Allergy Immunol., 2020.31, 920-929, DOI: https://doi.org/10.1111/pai.13308


Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype depending on genetic risk in school children

Hea Young Oh, So-Yeon Lee; Jisun Yoon; Hyun-Ju Cho; Young-Ho Kim; Dong In Suh; Song-I Yang; Ji-Won Kwon; Gwang Cheon Jang; Yong Han Sun; Sung-Il Woo; You-Sook Youn; Kang Seo Park; Hwa Jin Cho; Myung-Hee Kook; Hye Ryoung Yi; Hai Lee Chung; Ja Hyeong Kim; Hyung Young Kim; Sungsu Jung; Jin-A Jung; Hyang-Ok Woo; Kyeong Ok Koo; Sung-Ok Kwon; Jeom-Kyu Lee; Woo-Sung Chang; Eunseol Kim; Jeongrim Lee; Sangrok Kim; Soo-Jong Hong


Abstract

    Background: The effect of diet on allergic rhinitis (AR), its severity in children, and whether it modifies AR depending on genetic susceptibility are unknown. We investigated the association between dietary patterns and AR in school children and the influence of diet on AR according to a genetic risk score (GRS).

    Methods: Totally, 435 7-year-old school children were recruited from the Panel Study on Korean Children. We used dietary patterns (vegetable, sugar, and meat) and dietary inflammatory index (DII) as dietary parameters. AR and its severity were defined by questionnaires about treatment in the previous 12 months and the Allergic Rhinitis and its Impact on Asthma (ARIA) guideline, respectively. A GRS was calculated using 6 single nucleotide polymorphisms for allergic diseases.

    Results: A vegetable diet containing a lot of anti-inflammatory nutrients and higher vitamin D level in blood were negatively correlated, while DII was positively correlated with triglyceride level and triglyceride/HDL cholesterol. Vegetable diet (aOR, 95% CI = 0.73, 0.58-0.94) and DII (1.13, 1.01-1.28) were associated with AR risk. In particular, a high-vegetable diet resulted in a lower risk of mild and persistent AR (aOR, 95% CI = 0.24, 0.10-0.56) while a high DII represented a higher risk (2.33, 1.06-5.10). The protective effect of vegetable diet on AR appeared only among children with a lower GRS (adjusted P = .018).

    Conclusions: A vegetable dietary pattern characterized by high intake of anti-inflammatory nutrients and higher vitamin D level in blood might be associated with a lower risk of mild and persistent AR. This beneficial effect is modified by a genetic factor.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
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