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Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children ...
  • Date2021-02-23 16:45
  • Update2021-02-23 16:45
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

Allergy Asthma Immunol Res., 2020.12(1), 72-85, DOI: https://doi.org/10.4168/aair.2020.12.1.72


Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification

Sungsu Jung, So-Yeon Lee ; Jisun Yoon ; Hyun-Ju Cho ; Young-Ho Kim ; Dong In Suh ; Song-I Yang ; Ji-won Kwon ; Gwang Cheon Jang; Yong Han Sun ; Sung-Il Woo ; You-Sook Youn; Kang Seo Park ; Eun Lee; Hwa Jin Cho ; Myung-Hee Kook; Hye Ryoung Yi; Hai Lee Chung ; Ja Hyeong Kim ; Hyung Young Kim ; Jin A Jung; Hyang-Ok Woo


Abstract

    Purpose: Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study.

    Methods: We enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed.

    Results: The prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to Dermatophagoides Pteronyssinus (Der p), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77–15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40–40.74).

    Conclusions: Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
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