Go to main contents Go to main menus

사용자별 맞춤메뉴

자주찾는 메뉴

추가하기
닫기

Research Articles

contents area

detail content area

Panel-Reactive and Donor-Specific Antibodies before Lung Transplantation can Affect Outcomes in ...
  • Date2021-02-23 16:42
  • Update2021-02-23 16:42
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

Yonsei medical journal, 2020.61(7), 606-613, DOI: https://doi.org/10.3349/ymj.2020.61.7.606


Panel-Reactive and Donor-Specific Antibodies before Lung Transplantation can Affect Outcomes in Korean Patients Receiving Lung Transplantation

Song Yee Kim, Sung Woo Moon ; Moo Suk Park ; Jin Gu Lee ; Hyo Chae Paik ; Young Tae Kim ; Hyun Joo Lee ; Samina Park ; Sun Mi Choi ; Do Hyung Kim ; Woo Hyun Cho ; Hye Ju Yeo ; Seung Il Park ; Se Hoon Choi ; Sang Bum Hong ; Tae Sun Shim ; Kyung Wook Jo ; Kyeongman Jeon ; Byeong Ho Jeong; Korean Organ Transplantation Registry Study Group


Abstract


    Purpose: Data on the distribution and impact of panel reactive antibodies (PRA) and donor specific antibodies (DSA) before lung transplantation in Asia, especially multi-center-based data, are limited. This study evaluated the prevalence of and effects of PRA and DSA levels before lung transplantations on outcomes in Korean patients using nationwide multicenter registry data.
    Materials and methods: This study included 103 patients who received a lung transplant at five tertiary hospitals in South Korea between March 2015 and December 2017. Mortality, primary graft dysfunction (PGD), and bronchiolitis obliterans syndrome (BOS) were evaluated.
    Results: Sixteen patients had class I and/or class II PRAs exceeding 50%. Ten patients (9.7%) had DSAs with a mean fluorescence intensity (MFI) higher than 1000, six of whom had antibodies with a high MFI (≥2000). DSAs with high MFIs were more frequently observed in patients with high-grade PGD (≥2) than in those with no or low-grade (≤1) PGD. In the 47 patients who survived for longer than 9 months and were evaluated for BOS after the transplant, BOS was not related to DSA or PRA levels. One-year mortality was more strongly related to PRA class I exceeding 50% than that under 50% (0% vs. 16.7%, p=0.007).
    Conclusion: Preoperative DSAs and PRAs are related to worse outcomes after lung transplantation. DSAs and PRAs should be considered when selecting lung transplant recipients, and recipients who have preoperative DSAs with high MFI values and high PRA levels should be monitored closely after lung transplantation.
    Keywords: Transplantation immunology; bronchiolitis obliterans; lung transplantation; mortality; primary graft dysfunction.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
TOP