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- Date2021-02-23 16:41
- Update2021-02-23 16:41
- CountersignatureDivision of Research Planning
Transplantation proceedings, 2020.52(6), 1744-1748, DOI: https://doi.org/10.1016/j.transproceed.2020.03.005
Kidney Donor Risk Index (KDRI) score is more reliable than Kidney Donor Profile Index (KDPI) in kidney transplantation from elderly deceased donors.
Heungman Jun, Hye Eun Yoon; Kang Wook Lee ; Dong Ryeol Lee ; Jaeseok Yang ; Curie Ahn ; Sang Youb Han; Korean Organ Transplantation Registry Study Group
Background: It is unclear whether both Kidney Donor Profile Index (KDPI) and Kidney Donor Risk Index (KDRI) scores can be applied to elderly deceased donors (DDs). This study aimed to compare the predictive values of KDRI and KDPI for the occurrence of delayed graft function (DGF) in kidney transplantation (KT) from elderly DDs.
Methods: The data for 1049 DD KTs from the database of the Korean Organ Transplant Registry were reviewed retrospectively.
Results: The mean age of the 1049 DDs was 50.94 ± 10.57 years. A total of 224 DDs were ≥60 years old (21.35%). The mean KDRI and KDPI were 1.24 ± 0.40 and 63.58 ± 25.16, respectively. Ninety (8.6%) recipients had DGF postoperatively. The right-skewed distributions of KDRI in both elderly and nonelderly DDs were similar. However, the KDPI curve showed a sharp increase from a KDPI score of 60 in DDs aged ≥60 years. The areas under the curve (AUCs) of receiver operator characteristics (ROC) for KDPI and KDRI were different. In DDs aged <60 years, the estimated AUCs of ROC showed significant values for KDPI (0.577, 95% confidence interval, 0.503-0.637; P = .048) and KDRI (0.576, 0.505-0.639; P = .043). However, in DDs aged ≥60 years, KDRI score, not KDPI, was a significant value: KDRI, 0.633 (0.498-0.767; P = .034); KDPI, 0.530 (0.476-0.643; P = .138).
Conclusion: KDRI was more reliable in predicting graft outcome than KDPI in KT from elderly DDs. A longer follow-up period is needed to assess predictors for postoperative renal functions.
- DOI: https://doi.org/10.1016/j.transproceed.2020.03.005
- ISBN or ISSN: 0041-1345
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- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.