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Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean ...
  • Date2021-02-23 16:38
  • Update2021-02-23 16:38
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

Respiratory Research, 2020.21(1), 1-8, DOI: https://doi.org/10.1186/s12931-020-1289-2


Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data

Kyeongman Jeon, Ryoung-Eun Ko; Jin Gu Lee; Song Yee Kim; Young Tae Kim; Sun Mi Choi; Do Hyung Kim; Woo Hyun Cho; Seung-Il Park; Kyung-Wook Jo; Hong Kwan Kim; Hyo Chae Paik; the Korean Organ Transplantation Registry Study Group


Abstract

    Background
    The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of this multicenter prospective observational cohort study was to evaluate lung transplantation outcomes in Korean Organ Transplantation Registry (KOTRY) patients for whom ECMO was used as a bridge to transplantation.

    Methods
    Between March 2015 and December 2017, a total of 112 patients received lung transplantation and were registered in the KOTRY, which is a prospective, multicenter cohort registry. The entire cohort was divided into two groups: the control group (n = 85, 75.9%) and bridge-ECMO group (n = 27, 24.1%).

    Results
    There were no significant differences in pre-transplant and intraoperative characteristics except for poorer oxygenation, more ventilator use, and longer operation time in the bridge-ECMO group. The prevalence of primary graft dysfunction at 0, 24, 48, and 72 h after transplantation did not differ between the two groups. Although postoperative hospital stays were longer in the bridge-ECMO group than in the control group, hospital mortality did not differ between the two groups (25.9% vs. 13.3%, P = 0.212). The majority of patients (70.4% of the bridge-ECMO group and 77.6% of the control group) were discharged directly to their homes. Finally, the use of ECMO as a bridge to lung transplantation did not significantly affect overall survival and graft function.

    Conclusions
    Short- and long-term post-transplant outcomes of bridge-ECMO patients were comparable to recipients who did not receive ECMO.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
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