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Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive...
  • Date2021-02-23 16:35
  • Update2021-02-23 16:35
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

Alzheimer Disease & Associated disorders, 2020.34, 275-277, DOI: https://doi.org/10.1097/WAD.0000000000000396


Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy

Kyung Hye Kim, Jae Deuk Seo; Eun Soo Kim; Hyang-Sook Kim; Sumin Jeon; Kyoungjune Pak; Myung Jun Lee; Jae-Hyeok Lee; Young Min Lee; Kangyoon Lee; Jin-Hong Shin; Jun Kyeung Ko; Na-Yeon Jung; Jae Meen Lee; Jin A. Yoon; Chungsu Hwang; Jae-Woo Ahn; Suk Sung; Salvatore Spina; William W. Seeley; Kyung-Un Choi; Gi Yeong Huh; and Eun-Joo Kim


Abstract

    Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ1-42) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ1-42 and amyloid PET, several studies also reported discrepancies between these 2 Aβ biomarkers.We conducted a comparison of CSF Aβ1-42 level, amyloid PET, and autopsy findings in a case with progressive supranuclear palsy in which biomarker acquisition and postmortem pathologic examination were conducted almost at the same time. Our case with antemortem CSF Aβ1-42 (+)/amyloid PET (−) who was pathologically confirmed with Aβ pathology in the cerebral cortex may indicate CSF Aβ1-42 is more sensitive for assessing in vivo Aβ than amyloid PET.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
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