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THERPA

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    'THERPA is a public small molecule database related to prion protein regulation and prion disease progression.'


      Prion diseases (PrDs) are rare, fatal, neurodegenerative disorders that affect humans and animals. The pathology of PrDs is characterized by abnormal accumulation of misfolding prion protein (PrPSc), affecting the central nervous system. Despite the efforts till date to attenuate and cure PrD progression, no effective therapy has been realized. Small molecules that interact with proteins influence the biological processes in living organisms. These molecules have been used to attenuate and treat some diseases and bacterial infections. Various small molecules have been used to inhibit PrPSc accumulation or to cure PrDs. Collecting information and integrated interpretation of these small molecules is important to better understand the complicated mechanisms of PrDs and to identify new treatments. Thus, we built a therapeutic molecules database that is prion diseases-associated (THERPA).


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