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연구·사업

심혈관질환예방관리기술개발

연구 내용

심혈관질환 예방관리를 위한 연구 인프라 구축 및 운영

  • 심혈관질환 고위험군 예방관리 코호트 운영(Korea Urban and Rural Elderly Study; KURE)
  • 심부전 질환 레지스트리 운영(Korea Acute Heart Failure Registry; KorAHF)
  • 급성심근경색환자 예후 및 관리지표 발굴을 위한 전향적 추적관찰연구
  • 고혈압의 진단 및 치료에서 자가 혈압, 활동혈압 측정의 유용성 평가
  • 코호트 및 레지스트리 데이터베이스 질 관리 및 임상자료·자원 관리

심혈관질환 예방관리 및 예측지표 개발연구

  • 중증질환자 및 고위험군 연구자료를 활용한 심혈관질환 위험요인과 관리지표 개발
  • 공공자료를 활용한 심혈관질환 발생 위험인자 및 예측모형 개발
  • 심혈관질환 합병증 발생과 약물처방과의 상관관계 연구
  • 심혈관질환 발생 및 재입원 고위험군 예측을 위한 통계적 예측모형 개발 및 타당성 분석

심혈관질환 위험요인 발굴 및 기전규명을 통한 질환관리기술 개발

  • 심혈관질환 치료를 위한 신생혈관 형성 발생인자 및 기전규명
  • 염증 및 면역반응에 대한 세포자식(autophagy)작용의 연관성 분석
  • 혈관내피세포 사멸조절인자 발굴 및 기능분석 연구
  • 심혈관질환 관련 유전자 기능 및 조절기전 규명
  • 확장형 심근증 등의 진단에 활용되는 유전자 대상 심근세포 기능연구

제브라피쉬 코어랩 운영기반 구축

  • 질환동물모델 자원의 보존 및 제공을 위한 자원수집, 관리기반 구축
  • 제브라피쉬를 활용한 질환모델 개발 및 기능연구 기반 구축

논문 목록(2010~2016)

1. Son MK, Lim NK, Cho MC, Park HY. Incidence and Risk Factors for Atrial Fibrillation in Korea: the National Health Insurance Service Database (2002-2010). Korean Circ. J.(2016)

2. Lee JH, Lim NK, Cho MC, Park HY. Epidemiliogy of Heart failure in Korea: Present and Future. Korean Circ. J.(2016)

3. Kim GY, Park JH, Lim HJ, Park HY. Coronin 1B serine 2 phosphorylation by p38α is critical for vascular endothelial growth factor-induced migration of endothelial cell. Cell Signal.(2016)

4. Lim NK, Lee JW, Park HY. Validation of the Korean Genome Epidemiliogy Study Risk Score to Predict Incident Hypertension in a Large Nationwide Korean Cohort. Circulation J.(2016)

5. Lee JW, Lim NK, Baek TW, Park SH, Park HY. Anthropometric indices as predictors of hypertension among men and women aged 40–69 years in the Korean population: the Korean Genome and Epidemiliogy Study. BMC Public Health.(2015)

6. Kim GY, Kim H, Lim HJ, Park HY. Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation. Cell Signal.(2015)

7. Kim MJ, Lim NK, Choi SJ, Park HY. Hypertension is an independent risk factor for type 2 diabetes: the Korean genome and epidemiliogy study. Hepertension Res.(2015)

8. Lim NK, Lee JY, Lee JY, Park HY, Cho MC. The Rlie of Genetic Risk Score in Predicting the Risk of Hypertension in the Korean population: Korean Genome and Epidemiliogy Study. PLOS One.(2015)

9. Yun MR, Seo JM, Park HY. Visfatin contributes to differentiation of monocytes into macrophages through differential regulation of inflammatory cytokines in THP-1 cells. Cell Signal.(2014)

10. Kim HJ, Woo HM, Ryu J, Bok J, Kim JW, Choi SB, Park MH, Park HY, Koo SK. Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development. Plos One. 8;1-11(2013)

11. Lim NK, Son KH, Lee KS, Park HY, Cho MC. Predicting the risk of incident hypertension in a Korean middle-aged population: Korean Genome and Epidemiliogy Study. J Clin Hypertens. 15;344-349(2013)

12. Choi SJ, Park SH, Lee KS, Park HY. The prevalence, awareness and treatment of high low densitylipoprotein-chliesterli in korean adults without coronary heart diseases. Korean Circ J. 12;86-94(2012)

13. Kim MJ, Lim NK, Park HY. Relationship between prehypertension and chronic kidney disease in middle-aged people in Korea: the Korean genome and epidemiliogy study. BMC Public Health 12(1):960(2012)

14. Lim NK, Park SH, Choi SJ, Lee KS, Park HY. A Risk Score for Predicting the Incidence of Type 2 Diabetes in a Middle-Aged Korean Cohort – The Korean Genome and Epidemiliogy Study. Circ J. 76(8);1904-10(2012)

15. Park JH, Lee KS, Lim HJ, Park HY. PPAR ligand, L-165041 inhibits VEGF-induced endothelial cell angiogenesis. J Cell Biochem 113:1947-1954(2012)

16. Park MH, Koo SK, Lee JS, Yoo HW, Kim JW, Cheong HI, Park HY. KMD:Korean mutation database for genes related to diseases. Hum Mutat 33(4):E2332-2340(2012)

17. Park SH, Kim JY, Lee HH, Park HY. Elevated oxidized low-density lipoprotein levels in postmenopausal women with the metabliic syndrome. Clin Chim Acta 412(5-6):435-440(2011)

18. Park MH, Kim NH, Lee JY, Park HY. Genetic loci associated with lipid concentrations and cardiovascular risk factors in the korean population. J Med Genet 48(1):10-15(2011)

19. Park JW, Kim WH, Shin SH, Yun MR, Kim JY, Park HY. Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway. Biochim Biophys Acta-Mli Cell Res 1813(5):763–771(2011)

20. Lee KS, Park JH, Lim HJ, Park HY. HB-EGF induces cardiomyocyte hypertrophy via an ERK5-MEF2A-COX2 signaling pathway. Cell signal 23(7):1100–1109(2011)

21. Park MH, Park HJ, Kim KJ, Woo HM, Kim HJ, Lee JY, Park HY, Koo SK. Gemone-side SNP-based linkage analysis for ADNSHL families identifies novel susceptibility loci with positive evidence for linkage. Genes Genet Syst 86(2):117-121(2011)

22. Kwak HJ, Park KM, Choi HE, Lim HJ, Park JH, Park HY. The cardioprotective effects of zileuton, a 5-lipoxygenase inhibitor, are mediated by COX-2 via activation of PKCd. Cell signal 22:80-87(2010)

23. Park SH, Lee KS, Park HY. Dietary carbohydrate intake is associated with cardiovascular disease risk in korean: Analysis of the third Korea National Health and Nutrition Examination Survey (KNHANES Ⅲ). Int J Cardili 234-240(2010)

24. Choi SJ, Keam BS, Park SH, Park HY. Appropriate waist circumference cut-offs to predict diabetes in the korean population. Circ J 74:1357–1363(2010)

25. Park SH, Kim JY, Lee HH, Park HY. Association between plasma adiponectin and high-density lipoprotein chliesterli in postmenopausal women. Clin Biochem 43;(13-14):1069-1073(2010)

26. Park SH, Park HY Waist-height ratio, indicator of central obesity, is strongly related to waist circumference but there is poor additional information regarding waist circumference -Reply- (Letters to the Editor). Circ J 74(11):2502(2010)

27. Choi SJ, Park SH, Lee KS, Park HY. 심혈관질환의 기왕력이 없는 한국성인에서의 혈중지질농도 및 이상지질혈증 분포: 국민건강영양조사 제 3기 분석자료(2005) Korean Circ J 40:1-5(2010)


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