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업무분야

국가줄기세포은행 운영

  • (자원관리) 인간줄기세포자원 확보·품질관리·분양·정보제공
  • (국제표준화) 줄기세포은행 운영기반 국제표준기술확보
  • (재생의료연구) 전분화능줄기세포 품질평가, 질병 모델링 연구

인간배아줄기세포주 등록제 운영

  • 인간배아줄기세포주 이용을 위한 심의·등록

GMP 제조시설 운영

  • 임상연구용 줄기세포치료제 생산 지원

추진경과

추진경과
일 자 주요 내용
2008.6 「생명윤리 및 안전에 관한 법률」개정
2010.1 「생명윤리 및 안전에 관한 법률」에 따른 인간배아줄기세포주 등록 사업 개시
2012.7 국립줄기세포재생센터 건립 기본계획 수립
2012.10 질병관리본부내 국가줄기세포은행 개소
2014.3 국립줄기세포재생센터 착공식
2014.10 국가줄기세포은행 자원분양 개시
2016.10 국립줄기세포재생센터 개소식
2017.5 국가줄기세포은행 기탁등록보존기관 지정
2017.12 국립줄기세포재생센터 제조시설 검증 완료
2018.6 임상연구용 세포치료제 시범생산 성공
2018.8 임상연구용 세포치료제 제조지원 품목 선정
2018.10 임상연구용 세포치료제 제조지원 개시

논문목록(2014~)

  • Choi HY et al. Generation of a human induced pluripotent stem cell line, KSCBi003-A, from human adipose tissue-derived mesenchymal stem cells using a chromosomal integration-free system. Stem Cell Res. 2018.
  • Kurtz A et al. A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells. Stem Cell Reports. 2018.
  • Rim YA et al. Recent progress of national banking project on homozygous HLA-typed induced pluripotent stem cells in South Korea. J Tissue Eng Regen Med. 2018.
  • Kim BY et al. Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing. BMC Med Genet. 2017.
  • Kim BY et al. Optimized detection of insertions/deletions (INDELs) in whole-exome sequencing data. PLoS One. 2017.
  • Kim JH et al. Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. Stem Cells Transl Med. 2017.
  • Kim SJ et al. Generation of a Nrf2 homozygous knockout human embryonic stem cell line using CRISPR/Cas9. Stem Cell Res. 2017.
  • Kim SJ et al. A homozygous Keap1-knockout human embryonic stem cell line generated using CRISPR/Cas9 mediates gene targeting. Stem Cell Res. 2017.
  • Kim SJ et al. Generation of hematopoietic stem cells from human embryonic stem cells using a defined, stepwise, serum-free, and serum replacement-free monolayer culture method. Blood Res. 2017.
  • Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a modified RNA system. Stem Cell Res. 2017.
  • Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a modified RNA system. Stem Cell Res. 2017.
  • Uhm KO et al. Generation of human induced pluripotent stem cells from urinary cells of a healthy donor using a non-integration system. Stem Cell Res. 2017.
  • Jo HY et al. Application of whole-exome sequencing for detecting copy number variants in CMT1A/HNPP. Clin Genet. 2016.
  • Kim BJ et al. Discovery of CDH23 as a Significant Contributor to Progressive Postlingual Sensorineural Hearing Loss in Koreans. PLoS One. 2016.
  • Kim JY et al. HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation. Stem Cells Int. 2016.
  • Andrews PW et al. Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI). Regen Med. 2015.
  • Isasi R et al. Identifiability and privacy in pluripotent stem cell research. Cell Stem Cell. 2014.
  • Kim HJ et al. Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014.
  • Park MH et al. Comprehensive analysis to improve the validation rate for single nucleotide variants detected by next-generation sequencing. PLoS One. 2014.
  • Park MH et al. Recessive C10orf2 mutations in a family with infantile-onset spinocerebellar ataxia, sensorimotor polyneuropathy, and myopathy. Neurogenetics. 2014.
  • Woo HM et al. Identification of CDH23 mutations in Korean families with hearing loss by whole-exome sequencing. BMC Med Genet. 2014.
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