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Interethnic analyses of blood pressure loci in populations of East Asian and European descent
  • 작성일2019-05-14
  • 최종수정일2019-05-27
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 1,115
Nature Communications, 2018, 9(1), 5052─5052, DOI: https://doi.org/10.1038/s41467-018-07345-0

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Fumihiko Takeuchi, Akira Narita; Woei-Yuh Saw; Sanghoon Moon; Cass;ra N. Spracklen; Jin-Fang Chai; Young-Jin Kim; Liang Zhang; Chaolong Wang; Huaixing Li; Honglan Li; Jer-Yuarn Wu; Rajkumar Dorajoo; Jovia L. Nierenberg; Ya Xing Wang; Jing He; Derrick A. Bennett; Atsushi Takahashi; Yukihide Momozawa; Makoto Hirata; Koichi Matsuda; Hiromi Rakugi; Eitaro Nakashima; Masato Isono; Matsuyuki Shirota; Atsushi Hozawa; Sahoko Ichihara; Tatsuaki Matsubara; Ken Yamamoto; Katsuhiko Kohara; Michiya Igase; Sohee Han; Penny Gordon-Larsen; Wei Huang; Nanette R. Lee; Linda S. Adair; Mi Yeong Hwang; Juyoung Lee; Miao Li Chee; Charumathi Sabanayagam; Wanting Zhao; Jianjun Liu; Dermot F. Reilly; Liang Sun; Shaofeng Huo; Todd L. Edwards; Jirong Long; Li-Ching Chang; Chien-Hsiun Chen; Jian-Min Yuan; Woon-Puay Koh; Yechiel Friedl;er; Tanika N. Kelly; Wen Bin Wei; Liang Xu; Hui Cai; Yong-Bing Xiang; Kuang Lin; Robert Clarke; Robin G. Walters; Iona Y. Millwood; Liming Li; John C. Chambers; Jaspal S. Kooner; Paul Elliott; Pim van der Harst; The International Genomics of Blood Pressure(iGEN-BP) Consortium; Zhengming Chen; Makoto Sasaki; Xiao-Ou Shu; Jost B. Jonas; Jiang He; Chew-Kiat Heng; Yuan-Tsong Chen; Wei Zheng; Xu Lin; Yik-Ying Teo; E-Shyong Tai; Ching-Yu Cheng; Tien Yin Wong; Xueling Sim; Karen L. Mohlke; Masayuki Yamamoto; Bong-Jo Kim

Abstract

    Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.



  • 본 연구는 질병관리본부 연구개발과제(과제번호 2016-NI73001-02) 연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund(code 2016-NI73001-02) by Research of Korea Centers for Disease Control and Prevention.


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