본문으로 바로가기 주메뉴 바로가기

사용자별 맞춤메뉴

자주찾는 메뉴

추가하기
닫기

연구성과

contents area

detail content area

Regulatory variants in cancer-related pathway genes predict survival of patients with surgically resected non-small cell lung cancer.
  • 작성일2019-05-09
  • 최종수정일2019-05-09
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 697
Gene, 2018, 646, 56─63, DOI: https://doi.org/10.1016/j.gene.2017.12.055

Regulatory variants in cancer-related pathway genes predict survival of patients with surgically resected non-small cell lung cancer.

Kyung Min Shin, Cheng Cheng Jinb; Sun Ah Baekb; Jang Hyuck Leeb; Jin Eun Choib;e; Hyo-Gyoung Kangb;e; Won Kee Leef; Yangki Seokd;g; Eung Bae Leed;g; Ji Yun Jeongh; Seung Soo Yooc;d; Jaehee Leec; Seung Ick Chac; Chang Ho Kimc; Young Chul Kimi; In Jae Ohi; Kook Joo Naj; Sukki Chok; Sanghoon Jheonk; Jae Yong Park

Abstract

    Background: We conducted this study to identify genetic variants in cancer-related pathway genes which can predict prognosis of NSCLC patients after surgery, using a comprehensive list of regulatory single nucleotide polymorphisms (SNPs) prioritized by RegulomeDB.
    Method: A total of 509 potentially functional SNPs in cancer-related pathway genes selected from RegulomeDB were evaluated. These SNPs were analyzed in a discovery set (n =354), and a replication study was performed in an independent set (n =772). The association of the SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed.
    Results: In the discovery set, 76 SNPs were significantly associated with OS or DFS. Among the 76 SNPs, the association was consistently observed for 5 SNPs (ERCC1 rs2298881C > A, BRCA2 rs3092989G > A, NELFE rs440454C > T, PPP2R4 rs2541164G > A, and LTBP4 rs3786527G > A) in the validation set. In combined analysis, ERCC1 rs2298881C > A, BRCA2 rs3092989, NELFE rs440454C > T, and PPP2R4 rs2541164G > A were significantly associated with OS and DFS (adjusted HR ·aHR· for OS =1.46, 0.62, 078, and 0.76, respectively; P=0.003, 0.002, 0.007, and 0.003 respectively; and aHR for DFS =1.27, 0.69, 0.86, and 0.82, respectively; P =0.02, 0.002, 0.03, and 0.008, respectively). The LTBP4 rs3786527G > A was significantly associated with better OS (aHR=0.75; P= 0.003).
    Conclusion: Our results suggest that five SNPs in the cancer-related pathway genes may be useful for the prediction of the prognosis in patients with surgically resected NSCLC.



  • 본 연구는 질병관리본부 연구개발과제(과제번호 2018-보건의료생물자원종합관리) 연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund(code 2018-보건의료생물자원종합관리) by Research of Korea Centers for Disease Control and Prevention.


본 공공저작물은 공공누리  출처표시+상업적이용금지+변경금지 조건에 따라 이용할 수 있습니다 본 공공저작물은 공공누리 "출처표시+상업적이용금지+변경금지" 조건에 따라 이용할 수 있습니다.
TOP