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LINE-1 hypomethylation is inversely correlated with UHRF1 overexpression in gastric cancer
  • 작성일2019-05-09
  • 최종수정일2019-05-09
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 601
Oncology Letters, 2018, 15(5), 6666─6670, DOI: https://doi.org/10.3892/ol.2018.8121

LINE-1 hypomethylation is inversely correlated with UHRF1 overexpression in gastric cancer

Jang Hee Hong, SOYEON KIM; KYU‑SANG SONG; JAE KYU SUNG

Abstract

    DNA methylation is an important epigenetic modification that alters gene expression; DNA hypomethylation contributes to tumorigenesis through multiple processes. In the present study, the methylation of long interspersed element‑1 (LINE‑1) in 95 gastric cancer (GC) tissues and matched adjacent normal tissues was investigated by pyrosequencing. LINE‑1 methylation was compared with the expression of ubiquitin‑like with PHD and ring‑finger protein 1 (UHRF1), an essential regulator of DNA methylation, using reverse tranion‑quantitative polymerase chain reaction. Significant hypomethylation of LINE‑1 and overexpression of UHRF1 were observed in GC tissues compared with the matched controls (P<0.001 and P=0.001, respectively). LINE‑1 hypomethylation was inversely correlated with UHRF1 overexpression in GC tissues (r=‑0.026, P=0.028). In addition, LINE‑1 hypomethylation in GC was significantly associated with Lauren's histological classification, tumor differentiation and background intestinal metaplasia (P=0.014, P=0.042 and P=0.034, respectively). These results suggest that LINE‑1 hypomethylation may be a potential biomarker for GC and it is indirectly regulated by UHRF1 overexpression.



  • 본 연구는 질병관리본부 연구개발과제(과제번호 2018-보건의료생물자원종합관리) 연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund(code 2018-보건의료생물자원종합관리) by Research of Korea Centers for Disease Control and Prevention.


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