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Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer
  • 작성일2019-05-09
  • 최종수정일2019-05-09
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 1,162
ANNALS OF SURGICAL ONCOLOGY, 2018, 25(11), 3396─3403, DOI: https://doi.org/10.1245/s10434-018-6677-1

Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer

Sook Kyung Do, Jeong JY; Lee SY; Choi JE; Hong MJ; Kang HG; Lee WK; Seok Y; Lee EB; Shin KM; Yoo SS; Lee J; Cha SI; Kim CH; Neugent ML; Goodwin J; Kim JW; Park JY

Abstract

    Background. This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with nonsmall cell lung cancer (NSCLC) after surgical resection.
    Methods. Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients’ survival was analyzed.
    Results. Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T[A and rs4658G[C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T[A was associated with significantly better OS (adjusted hazard ratio [aHR] = 0.57, 95% confidence interval [CI] = 0.34–0.94, P = 0.03, under dominant model), and rs4658G[C was associated with significantly worse OS (aHR = 1.91, 95% CI = 1.09–3.33, P = 0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend = 4 x 10-3).
    Conclusions. This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.



  • 본 연구는 질병관리본부 연구개발과제(과제번호 2018-보건의료생물자원종합관리) 연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund(code 2018-보건의료생물자원종합관리) by Research of Korea Centers for Disease Control and Prevention.


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