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Trajectories of Physiological Brain Aging and Related Factors in People Aged from 20 to over-80
  • 작성일2019-05-09
  • 최종수정일2019-05-09
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 525
Journal of Alzheimer’s disease, 2018, 65, 1237─1246, DOI: https://doi.org/10.3233/JAD-170537

Trajectories of Physiological Brain Aging and Related Factors in People Aged from 20 to over-80

Jin san Lee, Jinse Parkc; Kyung Won Parkd; Do-Young Kange; Young Nohf ; Byoung Seok Yeg; Han Soo Yoog;

Abstract

    Background/Objective: In this study, we investigated a long-term trajectory of brain aging (from the 20 s to over-80) in cognitively normal (CN) individuals.We further determined whether differences in sex, education years, and apolipoprotein E 4 status affect age-related cortical thinning.
    Methods: A total of 2,944 CN individuals who underwent high-resolution (3.0-Tesla) magnetic resonance imaging were included in this study. Cortical thickness was measured using a surface-based method. Multiple linear regression analyses were performed to evaluate age-related cortical thinning and related factors.
    Results: Compared to those in their 20 s/30 s, participants in their 40 s showed thinning primarily in the medial and lateral frontal and inferior parietal regions, and cortical thinning occurred across most of the cortices with increasing age. Notably, the precuneus, inferior temporal and lateral occipital regions were relatively spared until later in life. Male and lower education years were associated with greater cortical thinning with distinct regional specificity.
    Conclusion: Our findings provide an important clue to understanding the mechanism of age-related cognitive decline and new strategies for preventing the acceleration of pathological brain aging.



  • 본 연구는 질병관리본부 연구개발과제(과제번호 2018-ER6203-00) 연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund(code 2018-ER6203-00) by Research of Korea Centers for Disease Control and Prevention.


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