본문으로 바로가기 주메뉴 바로가기

사용자별 맞춤메뉴

자주찾는 메뉴

추가하기
닫기

연구성과

contents area

detail content area

A nomogram for predicting amyloid PET positivity in amnestic mild cognitive impairment
  • 작성일2019-05-09
  • 최종수정일2019-05-09
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 1,179
Journal of Alzheimer’s disease, 2018, 66, 681─691, DOI: https://doi.org/10.3233/JAD-180048

A nomogram for predicting amyloid PET positivity in amnestic mild cognitive impairment

Si Eun Kim, Sookyoung Woo; Seon Woo Kim; Juhee Chin; Hee Jin Kim; Byung In Lee; Jinse Park; Kyung Won Park; Do-Young Kang; Young Noh ; Byoung Seok Ye; Han Soo Yoo; Jin San Lee; Yeshin Kim; Seung Joo Kim; Soo Hyun Cho; Duk L. Na; Samuel N. Lockhart; Hyemin Jang; Sang Won Seo

Abstract

    Background: Most clinical trials focus on amyloid- positive (A +) amnestic mild cognitive impairment (aMCI), but screening failures are high because only a half of patients with aMCI are positive on A PET. Therefore, it becomes necessary for clinicians to predict which patients will have A biomarker.
    Objective:We aimed to compare clinical factors, neuropsychological (NP) profiles, and apolipoprotein E (APOE) genotype between A + aMCI and A – aMCI and to develop a clinically useful prediction model of A positivity on PET (PET-A +) in aMCI using a nomogram.
    Methods:We recruited 523 aMCI patients who underwent A PET imaging in a nation-wide multicenter cohort. The results of NP measures were divided into following subgroups: 1) Stage (Early and Late-stage), 2) Modality (Visual, Verbal, and Both), 3) Recognition failure, and 4) Multiplicity (Single and Multiple). A nomogram for PET-A + in aMCI patients was constructed using a logistic regression model.
    Results: PET-A + had significant associations with NP profiles for several items, including high Clinical Dementia Rating Scale Sum of Boxes score (OR 1.47, p = 0.013) and impaired memory modality (impaired both visual and verbal memories compared with visual only, OR 3.25, p = 0.001). Also, presence of APOE ε4 (OR 4.14, p < 0.001) was associated with PET-A +. These predictors were applied to develop the nomogram, which showed good prediction performance (C-statistics = 0.79). Its prediction performances were 0.77/0.74 in internal/external validation.
    Conclusions: The nomogram consisting of NP profiles, especially memory domain, and APOE ε4 genotype may provide a useful predictive model of PET-A + in patients with aMCI.



  • 본 연구는 질병관리본부 연구개발과제(과제번호 2018-ER6203-00) 연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund(code 2018-ER6203-00) by Research of Korea Centers for Disease Control and Prevention.


본 공공저작물은 공공누리  출처표시+상업적이용금지+변경금지 조건에 따라 이용할 수 있습니다 본 공공저작물은 공공누리 "출처표시+상업적이용금지+변경금지" 조건에 따라 이용할 수 있습니다.
TOP